Mirtazapina [Inn-Spanish]
Brand names,
Mirtazapina [Inn-Spanish]
Analogs
Mirtazapina [Inn-Spanish]
Brand Names Mixture
Mirtazapina [Inn-Spanish]
Chemical_Formula
C17H19N3
Mirtazapina [Inn-Spanish]
RX_link
http://www.rxlist.com/cgi/generic/mirtaz.htm
Mirtazapina [Inn-Spanish]
fda sheet
Mirtazapina [Inn-Spanish]
msds (material safety sheet)
Mirtazapina [Inn-Spanish]
Synthesis Reference
W. J. Van der Burg, U.S. Pat. 4,062,848 (1977)
Mirtazapina [Inn-Spanish]
Molecular Weight
265.353 g/mol
Mirtazapina [Inn-Spanish]
Melting Point
114-116oC
Mirtazapina [Inn-Spanish]
H2O Solubility
Slight
Mirtazapina [Inn-Spanish]
State
Solid
Mirtazapina [Inn-Spanish]
LogP
2.369
Mirtazapina [Inn-Spanish]
Dosage Forms
Tablet; Tablet (orally disintegrating)
Mirtazapina [Inn-Spanish]
Indication
For the treatment of major depressive disorder.
Mirtazapina [Inn-Spanish]
Pharmacology
Mirtazapine, an antidepressant of the piperazinoazepine class, is a tetracyclic compound with an anxiolytic effect. Mirtazapine has fewer ADRs than tricyclic antidepressants and is better tolerated. Selective blockade of specific serotonin receptors by mirtazapine likey minimizes side effects typical of other antidepressants.
Mirtazapina [Inn-Spanish]
Absorption
Rapid and complete, but, due to first-pass metabolism, absolute bioavailability is 50%.
Mirtazapina [Inn-Spanish]
side effects and Toxicity
Symptoms of overdose include disorientation, drowsiness, impaired memory, and tachycardia. LD50=mg/kg (orally in rat).
Mirtazapina [Inn-Spanish]
Patient Information
Mirtazapina [Inn-Spanish]
Organisms Affected
Humans and other mammals